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GLP-1 (glucagon-like peptide 1) is a receptor agonist, a class of drugs originally designed to treat type 2 diabetes, with brand names such as Ozempic, Wegovy, and Mounjaro

The largest Wegovy trial (STEP program) reported an average ~15% body weight loss, which is markedly higher than results from older drugs like orlistat or appetite suppressants (typically 510%)

This means the heart cannot supply enough blood to meet the bodys needs, causing symptoms like fatigue, shortness of breath, and fluid buildup in the legs and lungs

The compound showed an in vitro NNMT IC 50 of approximately 1.2 M and did not inhibit related methyltransferases at concentrations tested

Lillys Zepbound helped people lose 22.5% of their body weight on average after 72 weeks in clinical trials

So, while there are problems there are also solutions